Effect of vitamin E in nonalcoholic fatty liver disease with metabolic syndrome: A propensity score-matched cohort study
Clinical and Molecular Hepatology
; : 379-386, 2015.
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| ID: wpr-91725
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ABSTRACT
BACKGROUND/AIMS:
Vitamin E improves the biochemical profiles and liver histology in nonalcoholic steatohepatitis, but the role of vitamin E is not clearly defined in the management of nonalcoholic fatty liver disease (NAFLD) which includes both simple steatosis and steatohepatitis. Co-morbid metabolic syndrome increases the probability of steatohepatitis in NAFLD. In this study, we aimed to determine the short-term effects of vitamin E and off-treatment durability of response in a propensity-score matched cohort of NAFLD patients with metabolic syndrome.METHODS:
A retrospective cohort was constructed by retrieving 526 consecutive NAFLD patients from the electronic medical record data warehouse of a tertiary referral hospital in South Korea. Among them, 335 patients (63.7%) had metabolic syndrome and were eligible for vitamin E therapy. In order to assess the effect of vitamin E, propensity score matching was used by matching covariates between control patients (n=250) and patients who received vitamin E (n=85).RESULTS:
The PS-matched vitamin E group (n=58) and control group (n=58) exhibited similar baseline metabolic profiles. After 6 months of vitamin E therapy, the mean ALT levels decreased significantly compared to PS-matched control (P<0.01). The changes in metabolic profiles (body weight, lipid and glucose levels) did not differ between control and vitamin E groups during the study period.CONCLUSIONS:
Short-term vitamin E treatment significantly reduces ALT levels in NAFLD patients with metabolic syndrome, but metabolic profiles are not affected by vitamin E.
Texte intégral:
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Indice:
WPRIM
Sujet Principal:
Aspartate aminotransferases
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Vitamine E
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Poids
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Études rétrospectives
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Études de cohortes
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Syndrome métabolique X
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Alanine transaminase
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Score de propension
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République de Corée
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Stéatose hépatique non alcoolique
Type d'étude:
Etiology_studies
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Incidence_studies
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Observational_studies
Limites du sujet:
Adult
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Aged
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Female
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Humans
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Male
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Clinical and Molecular Hepatology
Année:
2015
Type:
Article