Cytotoxic diaporindene and tenellone derivatives from the fungus Phomopsis lithocarpus / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 874-880, 2021.
Article
de En
| WPRIM
| ID: wpr-922770
Bibliothèque responsable:
WPRO
ABSTRACT
Nine new compounds, including five natural rarely-occurring 2, 3-dihydro-1H-indene derivatives named diaporindenes E-I (1-5), and four new benzophenone analogues named tenellones J-M (6-9) were isolated from the deep-sea sediment-derived fungus Phomopsis lithocarpus FS508. All the structures for these new compounds were fully characterized on the basis of spectroscopic data, NMR spectra, and ECD calculation and single-crystal X-ray diffraction analysis. The potential anti-tumor activities of compounds 1-9 against four tumor cell lines SF-268, MCF-7, HepG-2, and A549 were evaluated using the SRB method. Compound 7 exhibited cytotoxic activity against the SF-268 cell line with an IC
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Structure moléculaire
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Cristallographie aux rayons X
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Lignée cellulaire tumorale
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Champignons
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Phomopsis (genre)
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Antinéoplasiques
langue:
En
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2021
Type:
Article