High IL-23+ cells infiltration correlates with worse clinical outcomes and abiraterone effectiveness in patients with prostate cancer / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 147-153, 2022.
Article
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| WPRIM
| ID: wpr-928543
Responsable en Bibliothèque :
WPRO
ABSTRACT
Individualized treatment of prostate cancer depends on an accurate stratification of patients who are sensitive to various treatments. Interleukin-23 (IL-23) was reported to play a significant role in prostate cancer. Here, we aimed to explore the clinical value of IL-23-secreting (IL-23+) cells in prostate cancer patients. We evaluated interleukin-23A (IL-23A) expression in The Cancer Genome Atlas database and retrospectively enrolled 179 treatment-naïve metastatic prostate cancer patients diagnosed in our institute between June 2012 and December 2014. IL-23+ cells were stained and evaluated via immunohistochemistry. Further, survival and multivariate Cox regression analyses were conducted to explore the prognostic value of IL-23+ cells. We found that IL-23A expression correlated with disease progression, while IL-23+ cells were clearly stained within prostate cancer tissue. Patients with higher Gleason scores and multiple metastatic lesions tended to have more IL-23+ cell infiltration. Further analyses showed that patients with higher levels of IL-23+ cells had significantly worse overall survival (hazard ratio [HR] = 2.996, 95% confidence interval [95% CI] 1.812-4.955; P = 0.001) and a higher risk of developing castration resistance (HR = 2.725, 95% CI 1.865-3.981; P = 0.001). Moreover, subgroup analyses showed that when patients progressed to a castration-resistant status, the prognostic value of IL-23+ cells was observed only in patients treated with abiraterone instead of docetaxel. Therefore, we showed that high IL-23+ cell infiltration is an independent prognosticator in patients with metastatic prostate cancer. IL-23+ cell infiltration may correlate with abiraterone effectiveness in castration-resistant prostate cancer patients.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Protocoles de polychimiothérapie antinéoplasique
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Études rétrospectives
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Résultat thérapeutique
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Survie sans rechute
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Interleukine-23
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Tumeurs prostatiques résistantes à la castration
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Acétate d'abiratérone
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Androstènes
Type d'étude:
Observational_studies
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Prognostic_studies
Limites du sujet:
Humans
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Male
langue:
En
Texte intégral:
Asian Journal of Andrology
Année:
2022
Type:
Article