Research Progress on the Mechanism of Tubulin in Megakaryopoiesis and Regulation of Platelet Count--Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 323-326, 2022.
Article
de Zh
| WPRIM
| ID: wpr-928714
Bibliothèque responsable:
WPRO
ABSTRACT
Tubulin affects platelets count through the control of mitosis and the formation of pro-platelets during the maturation of megakaryoblast to platelets. Tubulin is involved in maintaining the integrity of platelet skeleton, and also participates in the change of platelet morphology during platelet activation. Some new anti-tumor drugs targeting cell mitosis are trying to reduce the effect on tubulin in order to reduce the side effect of drugs on platelet formation. In some patients with thrombocytopenia, the variation and polymorphism of the tubulin gene affect the structure of microtubule multimers, which leads to the decrease of platelet formation. This review summarized the latest progresses of tubulin in the regulation of megakaryopoiesis and thrombopoiesis.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Numération des plaquettes
/
Tubuline
/
Plaquettes
/
Mégacaryocytes
/
Thrombopoïèse
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Journal of Experimental Hematology
Année:
2022
Type:
Article