Gene-lifestyle interaction on coronary heart disease in adult twins of China / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 649-654, 2022.
Article
de Zh
| WPRIM
| ID: wpr-935438
Bibliothèque responsable:
WPRO
ABSTRACT
Objective: To explore the gene-lifestyle interaction on coronary heart disease (CHD) in adult twins of China. Methods: Participants were selected from twin pairs registered in the Chinese National Twin Registry (CNTR). Univariate interaction model was used to estimate the interaction, via exploring the moderation effect of lifestyle on the genetic variance of CHD. Results: A total of 20 477 same-sex twin pairs aged ≥25 years were recruited, including 395 CHD cases, and 66 twin pairs both had CHD. After adjustment for age and sex, no moderation effects of lifestyles, including current smoking, current drinking, physical activity, intake of vegetable and fruit, on the genetic variance of CHD were found (P>0.05), suggesting no significant interactions. Conclusion: There was no evidence suggesting statistically significant gene-lifestyle interaction on CHD in adult twins of China.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Jumeaux
/
Jumeaux dizygotes
/
Jumeaux monozygotes
/
Chine
/
Maladie coronarienne
/
Maladies chez les jumeaux
/
Mode de vie
Type d'étude:
Prognostic_studies
Limites du sujet:
Adult
/
Humans
Pays comme sujet:
Asia
langue:
Zh
Texte intégral:
Chinese Journal of Epidemiology
Année:
2022
Type:
Article