Antiproliferative piperidine alkaloids from giant taro (Alocasia macrorrhiza) / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 541-550, 2022.
Article
de En
| WPRIM
| ID: wpr-939919
Bibliothèque responsable:
WPRO
ABSTRACT
The rhizome of giant taro (Alocasia macrorrhiza (L.) Schott), which is a highly adaptable wild plant, is a traditional Chinese herbal medicine. In the current study, the antiproliferative constituents of giant taro were investigated and six new (1-6) and four known piperidine alkaloids (7-10) were isolated from its rhizomes. Their chemical structures and absolute configurations were elucidated using various spectroscopic methods and the Mosher ester method. The isolated alkaloids were screened for the antiproliferative activity through MTT assay. The results indicated that piperidine alkaloids exerted potential antiproliferative activity against HepG2, AGS and MCF-7 tumor cells. Further researches showed that compounds 3-5 dose-dependently decreased the colony formation rate and induced the apoptosis of AGS cells, while compound 4 induced AGS cell death via the proapoptotic pathway. This study demonstrates that the piperidine alkaloids isolated from giant taro exhibit significant antitumor activity, which provides phytochemical evidence for further development and utilization.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pipéridines
/
Plantes
/
Rhizome
/
Alocasia
/
Alcaloïdes
Limites du sujet:
Humans
langue:
En
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2022
Type:
Article