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Effects of Morus alba L. and Natural Products Including Morusin on In Vivo Secretion and In Vitro Production of Airway MUC5AC Mucin / 결핵및호흡기질환
Article de En | WPRIM | ID: wpr-94665
Bibliothèque responsable: WPRO
ABSTRACT
BACKGROUND: It is valuable to find the potential activity of regulating the excessive mucin secretion by the compounds derived from various medicinal plants. We investigated whether aqueous extract of the root bark of Morus alba L. (AMA), kuwanon E, kuwanon G, mulberrofuran G, and morusin significantly affect the secretion and production of airway mucin using in vivo and in vitro experimental models. METHODS: Effect of AMA was examined on hypersecretion of airway mucin in sulfur dioxide-induced acute bronchitis in rats. Confluent NCI-H292 cells were pretreated with ethanolic extract, kuwanon E, kuwanon G, mulberrofuran G, or morusin for 30 minutes and then stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 hours. The MUC5AC mucin secretion and production were measured by enzyme-linked immunosorbent assay. RESULTS: AMA stimulated the secretion of airway mucin in sulfur dioxide-induced bronchitis rat model; aqueous extract, ethanolic extract, kuwanon E, kuwanon G, mulberrofuran G and morusin inhibited the production of MUC5AC mucin induced by PMA from NCI-H292 cells, respectively. CONCLUSION: These results suggest that extract of the root bark and the natural products derived from Morus alba L. can regulate the secretion and production of airway mucin and, at least in part, explains the folk use of extract of Morus alba L. as mucoregulators in diverse inflammatory pulmonary diseases.
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Texte intégral: 1 Indice: WPRIM Sujet Principal: Plantes médicinales / Soufre / Produits biologiques / Bronchite / Test ELISA / Modèles animaux / Morus / Éthanol / Maladies pulmonaires / Modèles théoriques Limites du sujet: Animals langue: En Texte intégral: Tuberculosis and Respiratory Diseases Année: 2014 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Plantes médicinales / Soufre / Produits biologiques / Bronchite / Test ELISA / Modèles animaux / Morus / Éthanol / Maladies pulmonaires / Modèles théoriques Limites du sujet: Animals langue: En Texte intégral: Tuberculosis and Respiratory Diseases Année: 2014 Type: Article