Dissolution behavior of aripiprazole tablets based on near infrared spectroscopy / 药学实践与服务
Journal of Pharmaceutical Practice and Service
; (12): 36-39, 2023.
Article
de Zh
| WPRIM
| ID: wpr-953756
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To establish a near infrared (NIR) quantitative model for the dissolution behavior of aripiprazole tablets. Methods The NIR spectra of aripiprazole tablets were collected and the dissolution tests were performed to determine the dissolution of each tablet at 3, 6, 9, 12, 15 and 30 min. The near infrared spectra regions of 4 000.00-4 396.90, 5 326.43-12 000.00 cm−1 were pretreated by Savitzky-Golay smoothing filter, and the dissolution behavior model was established by partial least squares method. Results The root mean square error of calibration (RMSEC) and the root mean square error of prediction (RMSEP) at different time points were analyzed. RMSEP was lower than 8%. The calibration correlation coefficient (RC) and the prediction correlation coefficient (RP) at different time points were above 0.95 (except for the point of 6 min). There was a good correlation between the NIR spectrum and the dissolution at each time point. Conclusion NIR spectroscopy could predict the dissolution behavior of aripiprazole tablets, which lays a foundation for online quality monitoring of tablets by NIR spectroscopy.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of Pharmaceutical Practice and Service
Année:
2023
Type:
Article