A meta-analysis of the prognostic value of pentraxin 3 for the patients with sepsis / 中国小儿急救医学

ABSTRACT

Objective:To investigate the prognostic value of pentraxin 3(PTX3)levels in patients with sepsis through meta-analysis.Methods:Databases including PubMed, The Cochrane Library, Embase, Web of Science, China Science and Technology Journal Database(VIP), China National Knowledge Infrastructure(CNKI), Wanfang Data and China Biology Medicine disc(CBM)from inception to April 2020 were searched for clinical studies that reported the relationship between PTX3 levels and the prognosis of patients with sepsis.Literature selection was based on inclusion and exclusion criteria.The quality of the included studies was evaluated with Newcastal-Ottawa scale and the Meta-analysis was conducted with Review Manager 5.3 software.Results:Ten studies with 1 710 cases were included.Meta-analysis results showed that compared with survivors, PTX3 levels of non-survivors significantly increased(in the random effects model, I2=95%, P<0.001), the combined standard mean difference between non-survivors and survivors was 1.31(95% CI 0.73-1.90). A combined analysis of six studies on the predictive value of PTX3 for 28-day mortality in patients with sepsis was carried out, and the pooled sensitivity was 0.799(95% CI 0.730-0.854), the pooled specificity was 0.735(95% CI 0.649-0.807), the pooled odds ratio was 11.02(95% CI 6.60-18.40), the pooled positive likelihood ratio was 3.02(95% CI 2.24-4.06), the pooled negative likelihood ratio was 0.27(95% CI 0.20-0.37), and the area under summary receiver operator characteristic was 0.83(95% CI 0.79-0.86). Conclusion:PTX3 has a good prognostic value for sepsis.