Research progress on structure, function and disease correlation of solute carrier family 4 / 生理学报
Acta Physiologica Sinica
; (6): 137-150, 2023.
Article
Dans Zh
| WPRIM
| ID: wpr-970114
Responsable en Bibliothèque :
WPRO
ABSTRACT
The solute carrier family 4 (SLC4) includes 10 members (SLC4A1-5, SLC4A7-11), which are expressed in multiple tissues in the human body. The SLC4 family members differ in their substrate dependence, charge transport stoichiometry and tissue expression. Their common function is responsible for the transmembrane exchange of multiple ions, which is involved in many important physiological processes, such as erythrocyte CO2 transport and the regulation of cell volume and intracellular pH. In recent years, many studies have focused on the role of SLC4 family members in the occurrence of human diseases. When SLC4 family members have gene mutations, a series of functional disorders will occur in the body, leading to the occurrence of some diseases. This review summarizes the recent progress about the structures, functions and disease correlation of SLC4 members, in order to provide clues for the prevention and treatment of related human diseases.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Protéines SLC4A
/
Mutation
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Acta Physiologica Sinica
Année:
2023
Type:
Article