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Advances of structure and mechanisms of bromodomain-containing protein 4 and its related research in tumors / 生物工程学报
Chinese Journal of Biotechnology ; (12): 132-148, 2023.
Article de Zh | WPRIM | ID: wpr-970364
Bibliothèque responsable: WPRO
ABSTRACT
The bromodomain and extraterminal domain (Bet) family are the regulators of the epigenome and also the pivotal driving factors for the expression of tumor related genes that tumor cells depend on for survival and proliferation. Bromodomain-containing protein 4 (Brd4) is a member of the Bet protein family. Generally, Brd4 identifies acetylated histones and binds to the promoter or enhancer region of target genes to initiate and maintain expression of tumor related genes. Brd4 is closely related to the regulation of multiple transcription factors and chromatin modification and is involved in DNA damage repair and maintenance of telomere function, thus maintaining the survival of tumor cells. This review summarizes the structure and function of Brd4 protein and the application of its inhibitors in tumor research.
Sujet(s)
Mots clés
Texte intégral: 1 Indice: WPRIM Sujet Principal: Facteurs de transcription / Protéines nucléaires / Histone / Protéines du cycle cellulaire / Domaines protéiques / Tumeurs Limites du sujet: Humans langue: Zh Texte intégral: Chinese Journal of Biotechnology Année: 2023 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Facteurs de transcription / Protéines nucléaires / Histone / Protéines du cycle cellulaire / Domaines protéiques / Tumeurs Limites du sujet: Humans langue: Zh Texte intégral: Chinese Journal of Biotechnology Année: 2023 Type: Article