Progress on the design and optimization of antimicrobial peptides / 生物医学工程学杂志
J. biomed. eng
; Sheng wu yi xue gong cheng xue za zhi;(6): 1247-1253, 2022.
Article
de Zh
| WPRIM
| ID: wpr-970664
Bibliothèque responsable:
WPRO
ABSTRACT
Antimicrobial peptides (AMPs) are a class of peptides widely existing in nature with broad-spectrum antimicrobial activity. It is considered as a new alternative to traditional antibiotics because of its unique mechanism of antimicrobial activity. The development and application of natural AMPs are limited due to their drawbacks such as low antimicrobial activity and unstable metabolism. Therefore, the design and optimization of derived peptides based on natural antimicrobial peptides have become recent research hotspots. In this paper, we focus on ribosomal AMPs and summarize the design and optimization strategies of some related derived peptides, which include reasonable primary structure modification, cyclization strategy and computer-aided strategy. We expect to provide ideas for the design and optimization of antimicrobial peptides and the development of anti-infective drugs through analysis and summary in this paper.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Conception de médicament
/
Peptides antimicrobiens cationiques
/
Peptides antimicrobiens
/
Anti-infectieux
/
Antibactériens
langue:
Zh
Texte intégral:
J. biomed. eng
/
Sheng wu yi xue gong cheng xue za zhi
Année:
2022
Type:
Article