Analysis of genetic variant in a child with Aspartylglucosaminuria / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 87-91, 2023.
Article
de Zh
| WPRIM
| ID: wpr-970884
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE@#To explore the genetic basis for a child with Aspartylglucosaminuria (AGU).@*METHODS@#Clinical data of the patient was analyzed. The child was subjected to trio-whole exome sequencing (WES) and copy number variation sequencing (CNV-seq), and candidate variant was verified by Sanger sequencing.@*RESULTS@#The child was found to harbor homozygous c.319C>T (p.Arg107*) nonsense variant of the AGA gene, for which both of his parents were heterozygous carriers. No abnormality was found by CNV-seq analysis. The c.319C>T (p.Arg107*) variant was not found in population database, HGMD and other databases. Based on guidelines of the American College of Medical Genetics and Genomics, the variant was predicted to be pathogenic (PVS1+PM2+PP3).@*CONCLUSION@#The c.319C>T variant of the AGA gene probably underlay the autosomal recessive AGU in this child. Above finding has enabled genetic counseling and prenatal diagnosis for his parents.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Génomique
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Aspartylglucosaminurie
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Variations de nombre de copies de segment d'ADN
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Conseil génétique
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Hétérozygote
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Mutation
Limites du sujet:
Child
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Female
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Humans
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Pregnancy
langue:
Zh
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2023
Type:
Article