Fontan-associated liver disease current status and transplantation consideration / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 109-112, 2023.
Article
de Zh
| WPRIM
| ID: wpr-970961
Bibliothèque responsable:
WPRO
ABSTRACT
Fontan-associated liver disease (FALD) is one of the main complications after the Fontan procedure, manifesting mostly as liver fibrosis and even cirrhosis, with a high incidence rate and a lack of typical clinical symptoms that seriously affect patient prognosis. The specific cause is unknown, although it is considered to be associated with long-term elevated central venous pressure, impaired hepatic artery blood flow, and other relevant factors. The absence of association between laboratory tests, imaging data, and the severity of liver fibrosis makes clinical diagnosis and monitoring difficult. A liver biopsy is the gold standard for diagnosing and staging liver fibrosis. The most important risk factor for FALD is time following the Fontan procedure; therefore, it is recommended to do a liver biopsy 10 years after the Fontan procedure and to be cautious for the presence of hepatocellular carcinoma. Combined heart-liver transplantation is a recommended choice with favorable outcomes for patients with Fontan circulatory failure and severe hepatic fibrosis.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Complications postopératoires
/
Transplantation hépatique
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Carcinome hépatocellulaire
/
Procédure de Fontan
/
Foie
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Cirrhose du foie
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Maladies du foie
/
Tumeurs du foie
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Chinese Journal of Hepatology
Année:
2023
Type:
Article