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Transluminal Radio-Frequency Thermal Ablation Using a Stent-Type Electrode: an Experimental Study
Article de Ko | WPRIM | ID: wpr-97521
Bibliothèque responsable: WPRO
ABSTRACT
PURPOSE: To assess the feasibility of transluminal radiofrequency thermal ablation using a stent-type electrode and to determine, by means of in-vitro and in-vivo animal studies, the appropriate parameters. MATERIALS AND METHODS: In vitro: The radiofrequency electrode used was a self-expandable nitinol stent with 1cm insulated ends. A stent was placed in the portal vein of bovine liver, and ablations at target temperatures of 70, 80, 90, and 100degrees C were performed. Ablated sizes were measured longitudinally. In vivo: Four mongrel dogs were anesthetized, and a stent was inserted in the common bile duct under fluoroscopic guidance through an ultrasound-guided gall bladder puncture site. The ablation temperature was set at 80 degrees C, and each dog underwent proximal and distal esophageal ablations lasting 12 minutes. They were sacrificed immediately. RESULTS: In-vitro: Ablated sizes showed significant correlation with target temperatures (r>0.04; p<0.05). Although most lesions were fusiform, dumbbell-shaped lesions with central thinning were found in two cases in the 70degrees C group. In all cases in the 70 degrees C and 80 degrees C group, the length of the insulated segment was less than 1 cm. In-vivo: At microscopy, tissues at the center of the biliary stent showed more prominent pathological change than those at the periphery while those remote from the stent showed minimal or no change. In esophageal ablations, the mean highest temperature was 48.6 degrees C. Microscopy demonstrated the destruction and shedding of mucosa, edema, and coagulation necrosis of submucosa, but in muscle layers no abnormalities were apparent. CONCLUSION: Transluminal radio-frequency thermal ablation using a stent-type electrode may be useful for elongating patency. The appropriate target temperature for biliary ablation is 80 degrees C.
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Texte intégral: 1 Indice: WPRIM Sujet Principal: Veine porte / Vessie urinaire / Ponctions / Endoprothèses / Conduit cholédoque / Oedème / Électrodes / Foie / Microscopie / Muqueuse Limites du sujet: Animals langue: Ko Texte intégral: Journal of the Korean Radiological Society Année: 2003 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Veine porte / Vessie urinaire / Ponctions / Endoprothèses / Conduit cholédoque / Oedème / Électrodes / Foie / Microscopie / Muqueuse Limites du sujet: Animals langue: Ko Texte intégral: Journal of the Korean Radiological Society Année: 2003 Type: Article