Advances and prospects in targeted protein degradation / 药学实践与服务
Journal of Pharmaceutical Practice and Service
; (12): 341-351, 2023.
Article
de Zh
| WPRIM
| ID: wpr-976525
Bibliothèque responsable:
WPRO
ABSTRACT
Targeted protein degradation (TPD) techniques eliminate pathogenic proteins by hijacking the intracellular proteolysis machinery which includes the ubiquitin-proteasome system (UPS) and the lysosomal degradation pathway, holding promise to overcome the limitations of traditional inhibitors and further broaden the target space including many “undruggable” targets, and provide new targeted treatments for drug discovery. In this review, recent advances in a variety of promising TPD strategies were summarized, such as proteolysis targeting chimera (PROTAC), molecular glue, lysosome-targeting chimaera (LYTAC), autophagosome-tethering compound (ATTEC), autophagy-targeting chimera AUTAC and AUTOTAC, particularly. The representative case studies, potential applications and challenges were analyzed.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of Pharmaceutical Practice and Service
Année:
2023
Type:
Article