Progress of research on chromosomal mosaicism embryos / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 618-623, 2023.
Article
Dans Zh
| WPRIM
| ID: wpr-981800
Responsable en Bibliothèque :
WPRO
ABSTRACT
Chromosomal mosaicism (CM) is a common phenomenon in preimplantation genetic testing (PGT). In embryos with CM, genetic contents of trophoblastic ectodermal (TE) cells may be different from that of the inner cell mass (ICM) which will develop into the fetus. Embryos with low mosaic proportion could give rise to healthy live births after transplantation, but are accompanied with high pregnancy risks such as high abortion rate. In order to provide a more comprehensive understanding for CM embryos, this article has systematically summarized the recent progress of research on the definition, mechanism, classification, PGT techniques, self-correction mechanism, transplantation outcome and treatment principles for CM embryos.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Blastocyste
/
Dépistage génétique
/
Diagnostic préimplantatoire
/
Aneuploïdie
/
Mosaïcisme
Limites du sujet:
Female
/
Humans
/
Pregnancy
langue:
Zh
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2023
Type:
Article