Correlation between ARID5B Gene SNP and MTX Resistance in Children with ALL / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 333-337, 2023.
Article
Dans Zh
| WPRIM
| ID: wpr-982063
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE@#To investigate the correlation between single-nucleotide polymorphism (SNP) of ARID5B gene and resistance to methotrexate (MTX) in children with acute lymphoblastic leukemia (ALL).@*METHODS@#A total of 144 children with ALL who were treated in General Hospital of Ningxia Medical University from January 2015 to November 2021 were enrolled and divided into MTX resistant group and non-MTX resistant group, with 72 cases in each group. Matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) technology was used to measure the SNP of ARID5B gene in all children and analyze its correlation with MTX resistant.@*RESULTS@#There were no significant differences in the genotype and gene frequency of rs7923074, rs10821936, rs6479778, and rs2893881 between MTX resistant group and non-MTX resistant group (P>0.05). The frequency of C/C genotype in the MTX resistant group was significantly higher than that in the non-MTX resistant group, while the frequency of T/T genotype was opposite (P<0.05). The frequency of C allele in the MTX resistant group was significantly higher than that in the non-MTX resistant group, while the frequency of T allele was opposite (P<0.05). Multivariate logistic regression analysis showed that ARID5B gene rs4948488 TT genotype and T allele frequency were risk factors for MTX resistant in ALL children (P<0.05).@*CONCLUSION@#The SNP of ARID5B gene is associated with MTX resistant in ALL children.
Texte intégral:
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Indice:
WPRIM
Sujet Principal:
Facteurs de transcription
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Méthotrexate
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Résistance aux médicaments antinéoplasiques
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Polymorphisme de nucléotide simple
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Protéines de liaison à l'ADN
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Leucémie-lymphome lymphoblastique à précurseurs B et T
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Fréquence d'allèle
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Génotype
Limites du sujet:
Child
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Humans
langue:
Zh
Texte intégral:
Journal of Experimental Hematology
Année:
2023
Type:
Article