Progress in the Study of Spindle Assembly Checkpoint in Lung Cancer / 中国肺癌杂志
Chinese Journal of Lung Cancer
; (12): 310-318, 2023.
Article
Dans Zh
| WPRIM
| ID: wpr-982161
Responsable en Bibliothèque :
WPRO
ABSTRACT
Spindle assembly checkpoint (SAC) is a protective mechanism for cells to undergo accurate mitosis. SAC prevented chromosome segregation when kinetochores were not, or incorrectly attached to microtubules in the anaphase of mitosis, thus avoiding aneuploid chromosomes in daughter cells. Aneuploidy and altered expression of SAC component proteins are common in different cancers, including lung cancer. Therefore, SAC is a potential new target for lung cancer therapy. Five small molecule inhibitors of monopolar spindle 1 (MPS1), an upstream component protein of SAC, have entered clinical trials. This article introduces the biological functions of SAC, summarizes the abnormal expression of SAC component proteins in various cancers and the research progress of MPS1 inhibitors, and expects to provide a reference for the future development of lung cancer therapeutic strategies targeting SAC components.
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Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Protein-Serine-Threonine Kinases
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Protéines du cycle cellulaire
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Points de contrôle de la phase M du cycle cellulaire
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Tumeurs du poumon
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Appareil du fuseau
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Chinese Journal of Lung Cancer
Année:
2023
Type:
Article