Effects of curcumin on malondialdehyde and c-fos protein in hypoxia ischemia brain tissue in rats / 法医学杂志
Journal of Forensic Medicine
; (6): 6-8, 2009.
Article
de Zh
| WPRIM
| ID: wpr-983431
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE@#To explore the effects of curcumin on the content of malondialdehyde (MDA) and the expression level of c-fos protein following hypoxia ischemia brain damage (HIBD) in rats.@*METHODS@#Sprague-Dauley (SD) rats were randomly divided into four groups as the following: sham group, hypoxia ischemia brain damage group, curcumin group and solvent control group. The content of MDA in the brain was measured by colorimetry. The expression level of c-fos protein in the cortex tissue was detected by immunohistochemistry. Morphologic and structural changes of neuron cells of the cortex were observed by electron microscopy.@*RESULTS@#The content of MDA was clearly lower in curcumin group than that in the other groups at the same time after HIBD. The expression level of c-fos protein was higher in the curcumin group than that in the other groups (P<0.05). Electron microscopy showed that the morphologic and structural changes of neuron cells of cortex in the curcumin group were reduced.@*CONCLUSION@#Curcumin could significantly decrease the content of MDA, increase the expression level of c-fos protein and reduce the damage of the neuron cells.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Répartition aléatoire
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Protéines proto-oncogènes c-fos
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Rat Sprague-Dawley
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Neuroprotecteurs
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Hypoxie-ischémie du cerveau
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Curcumine
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Anatomopathologie légale
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Malonaldéhyde
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Neurones
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
Journal of Forensic Medicine
Année:
2009
Type:
Article