A Case of Hepatitis after Occupational Exposure of Trichloethylene / 대한간학회지
The Korean Journal of Hepatology
; : 59-64, 1999.
Article
de Ko
| WPRIM
| ID: wpr-98906
Bibliothèque responsable:
WPRO
ABSTRACT
Trichloroethylene (TCE) is currently used as a degreasing agent in the jewelry manufacturing industry. The characteristic sign arising after the exposure of TCE are hepatitis and contact dermatitis. The incidence of toxicity is relatively rare, therefore, the mechanism of occurrence is considered as hypersensitivity. A previously healthy 21-year-old male began to work at jewelry industry. The solvent used in that place was TCE. Over the next month, he experienced symptoms of weakness, fever, dry skin, red rash and bumps, peeling face, and jaundice. At that time, he had marked liver enzyme elevation with evidence of cholestasis. After two weeks of avoidance of TCE exposure, his liver enzymes showed a marked reduction in ALT from a peak of 1132 to 131 IU/L. The total bilirubin reduced from 9.3 to 4.6 mg/dL. Tests for hepatitis A, B, and C, CMV, HIV were all negative. The patch test showed primary irritant reaction to TCE and its metabolite, trichloroethanol. This is the second report of TCE induced hepatotoxicity in Korea. We consider this case as a TCE induced hepatotoxicity due to possibly hypersensitivity mechanism.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Peau
/
Trichloroéthylène
/
Bilirubine
/
Tests épicutanés
/
Cholestase
/
Incidence
/
Exposition professionnelle
/
VIH (Virus de l'Immunodéficience Humaine)
/
Eczéma de contact
/
Exanthème
Type d'étude:
Incidence_studies
/
Prognostic_studies
Limites du sujet:
Humans
/
Male
Pays comme sujet:
Asia
langue:
Ko
Texte intégral:
The Korean Journal of Hepatology
Année:
1999
Type:
Article