A narrative review on the research history of renal fibrosis from 1836 to 2000 / 中华肾脏病杂志

ABSTRACT

Renal fibrosis (RF) is the key pathological feature for the progression of chronic kidney disease to end-stage renal failure. It has been an important scientific issue to understand its mechanism of RF in the field of kidney diseases in the past near two centuries. The progress of science and technology has not only provided a strong tool for RF research, but also given us many new ideas for RF prevention and treatment. The paper briefly reviews the key histories of RF research, with focuses on early studies of renal fibrosis, application of renal biopsy technology, establishment of RF animal models, advancements in cell and molecular biotechnology, and exploration into mechanisms underlying RF, to clarify future directions for chronic kidney disease prevention and treatment research.