Research progress of SARS-CoV-2 main protease inhibitors / 药学学报
Acta Pharmaceutica Sinica
; (12): 2581-2600, 2023.
Article
de Zh
| WPRIM
| ID: wpr-999009
Bibliothèque responsable:
WPRO
ABSTRACT
As a common protease with high similarity among coronavirus species, the main protease (Mpro) of SARS-CoV-2 is responsible for the catalytic hydrolysis of viral precursor proteins into functional proteins, which is essential for coronavirus replication and is one of the ideal targets for the development of broad-spectrum antiviral drugs. This paper reviews the main protease inhibitors of SARS-CoV-2, including their molecular structures, potencies and drug-like profiles, binding modes and structure-activity relationships, etc.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2023
Type:
Article