Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition
Arch. endocrinol. metab. (Online)
; 64(1): 89-95, Jan.-Feb. 2020. graf
Article
em En
| LILACS
| ID: biblio-1088770
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT Clinical and subclinical hypothyroidism are the most common hormonal dysfunctions during pregnancy. Insufficient maternal thyroid hormones (THs) in the early stages of pregnancy can lead to severe impairments in the development of the central nervous system because THs are critical to central nervous system development. In the fetus and after birth, THs participate in neurogenic processes, cell differentiation, neuronal activation, axonal growth, dendritic arborization, synaptogenesis and myelination. Although treatment is simple and effective, approximately 30% of pregnant women in Brazil with access to prenatal care have their first consultation after the first trimester of pregnancy, and any delay in diagnosis and resulting treatment delay may lead to cognitive impairment in children. This review summarizes the effects of clinical and subclinical hypothyroidism on fetal neurodevelopment, behavior and cognition in humans and rodents. Arch Endocrinol Metab. 2020;64(1)89-95
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Texto completo:
1
Índice:
LILACS
Assunto principal:
Complicações na Gravidez
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Encéfalo
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Disfunção Cognitiva
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Hipotireoidismo
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Troca Materno-Fetal
Limite:
Animals
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Arch. endocrinol. metab. (Online)
Assunto da revista:
ENDOCRINOLOGIA
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METABOLISMO
Ano de publicação:
2020
Tipo de documento:
Article