Your browser doesn't support javascript.
loading
Clinical and epidemiological profile of HCV genotype 3 patients in southern Brazil
Costa, Marisa Boff; Longo, Larisse; Santos, Deivid; Costa, Raquel Boff da; Dellavia, Gustavo Hirata; Arruda, Soraia; Michalczuk, Matheus Truccolo; Álvares-da-Silva, Mário Reis.
Afiliação
  • Costa, Marisa Boff; Universidade Federal do Rio Grande do Sul (UFRGS). Programa de Pós-graduação em Gastroenterologia e Hepatologia. Porto Alegre. BR
  • Longo, Larisse; Universidade Federal do Rio Grande do Sul (UFRGS). Programa de Pós-graduação em Gastroenterologia e Hepatologia. Porto Alegre. BR
  • Santos, Deivid; Universidade Federal do Rio Grande do Sul (UFRGS). Faculdade de Medicina. Porto Alegre. BR
  • Costa, Raquel Boff da; Universidade Federal do Rio Grande do Sul (UFRGS). Programa de Pós-Graduação em Ciências Pneumológicas. Porto Alegre. BR
  • Dellavia, Gustavo Hirata; Universidade Federal do Rio Grande do Sul (UFRGS). Faculdade de Medicina. Porto Alegre. BR
  • Arruda, Soraia; Hospital de Clínicas de Porto Alegre (HCPA). Serviço de Gastroenterologia. Porto Alegre. BR
  • Michalczuk, Matheus Truccolo; Universidade Federal do Rio Grande do Sul (UFRGS). Programa de Pós-graduação em Gastroenterologia e Hepatologia. Porto Alegre. BR
  • Álvares-da-Silva, Mário Reis; Universidade Federal do Rio Grande do Sul (UFRGS). Programa de Pós-graduação em Gastroenterologia e Hepatologia. Porto Alegre. BR
Clin. biomed. res ; 40(1): 7-13, 2020.
Article em En | LILACS | ID: biblio-1115980
Biblioteca responsável: BR18.1
ABSTRACT

Introduction:

Despite the emergence of new treatments for HCV genotype 3 (HCV G3), there is still a lack of data about this particular subgroup in Brazil. Our objective was to describe clinical and sociodemographic variables and treatment profile of HCV G3 Brazilian patients.

Methods:

This was a descriptive, retrospective study, performed in a specialized center for HCV treatment in the South Region of Brazil. Medical records of patients diagnosed with HCV G3 were reviewed to collect clinical, sociodemographic, and treatment information.

Results:

Participants included total of 564 patients, with a mean age of 59.3 years (SD = 10.5). Cirrhosis was present in 54.4% of patients. The most common coexisting conditions were systemic arterial hypertension (36.6%) and diabetes mellitus (30%). Regarding treatment, 25.2% of the patients were treatment-naïve and 74.8% were currently under treatment (11.6%) or had received a previous treatment (87%). The most frequent ongoing treatment was sofosbuvir + daclatasvir (± ribavirin) (87.8%). Of the 388 patients who had at least one previous treatment, 67% achieved sustained virologic response in the last treatment. Caucasian / white, non-obese, transplanted patients, those with longer time since diagnosis and with cirrhosis were more likely to receive treatment, according to multivariate analysis. Patients with hepatocellular carcinoma were 64.1% less likely to be on treatment during the study period than those without this condition; patients with chronic kidney disease were 2.91-fold more likely to have an interruption of treatment than those without this condition.

Conclusion:

This study describes a large sample of Brazilian patients with HCV G3. Treatment patterns were mainly influenced by the presence of HCV complications and comorbidities.(AU)
Assuntos
Palavras-chave

Texto completo: 1 Índice: LILACS Assunto principal: Hepatite C / Hepacivirus / Genótipo Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Clin. biomed. res Assunto da revista: MEDICINA Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Índice: LILACS Assunto principal: Hepatite C / Hepacivirus / Genótipo Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Clin. biomed. res Assunto da revista: MEDICINA Ano de publicação: 2020 Tipo de documento: Article