DEC1: a potential biomarker of malignant transformation in oral leukoplakia
Braz. oral res. (Online)
; 34: e052, 2020. tab, graf
Article
em En
| LILACS, BBO
| ID: biblio-1132707
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract The purpose of this study was to analyze the differential expression of DEC1 in oral normal mucosa (NM), oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC). Surgically excised specimens from patients with OLK (n = 47), OSCC (n = 30) and oral normal mucosa (n=11) were immunostained for DEC1. The expression of DEC1 protein was evaluated, and its association with the clinicopathological features was analyzed. The expression of DEC1 in NM, OLK and OSCC tissues increased in turn, and significant differences were observed among the groups (P < 0.0001). In terms of the association between DEC1 expression and epithelial dysplasia, DEC1 expression was lower in hyperkeratosis without dysplasia (H-OLK) than in OLK with moderate to severe dysplasia (S-OLK), and these differences were significant (p < 0.05). The expression of DEC1 in OSCC with OLK was significantly higher than that in OSCC without OLK (p < 0.01). Therefore, DEC1 could be a potential biomarker of malignant transformation in the carcinogenesis of OSCC, which may provide a new research direction for the transformation of oral potentially malignant disorders (OPMDs) into OSCC.
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Texto completo:
1
Índice:
LILACS
Assunto principal:
Leucoplasia Oral
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Neoplasias Bucais
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Carcinoma de Células Escamosas
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Proteínas Supressoras de Tumor
Tipo de estudo:
Etiology_studies
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Evaluation_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Braz. oral res. (Online)
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article