The gene expression of Leishmania infantum chagasi inside Lutzomyia longipalpis, the main vector of visceral leishmaniasis in Brazil
Mem. Inst. Oswaldo Cruz
; 116: e200571, 2021. tab, graf
Article
em En
| LILACS
| ID: biblio-1154878
Biblioteca responsável:
BR1.1
ABSTRACT
Leishmania infantum chagasi is the causative agent and Lutzomyia longipalpis is the main vector of visceral leishmaniasis in the Americas. We investigated the expression of Leishmania genes within L. longipalpis after artificial infection. mRNAs from genes involved in sugar and amino acid metabolism were upregulated at times of high parasite proliferation inside the insect. mRNAs from genes involved in metacyclogenesis had higher expression in late stages of infection. Other modulated genes of interest were involved in immunomodulation, purine salvage pathway and protein recycling. These data reveal aspects of the adaptation of the parasite to the microenvironment of the vector gut and reflect the preparation for infection in the vertebrate.
Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Psychodidae
/
Leishmania infantum
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Insetos Vetores
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Leishmania
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Leishmaniose Visceral
Limite:
Animals
País/Região como assunto:
America do sul
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Brasil
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article