Naringin is a promising natural compound for therapy of iron-overload disorders
Braz. J. Pharm. Sci. (Online)
; 58: e19409, 2022. graf
Article
em En
| LILACS
| ID: biblio-1383963
Biblioteca responsável:
BR40.1
Localização: BR40.1
ABSTRACT
Abstract Naringin has been shown to exhibit satisfying iron chelation capacity. Considering the side effects of routinely-used iron chelator (desferrioxamine, DFO), we decided to evaluate the iron chelation potency of naringin to discover whether or not it can be a promising natural substitute for treatment of excessive iron-related diseases. 35 mice were classified into five groups of 7 and subjected to iron dextran administration to induce the iron-overload condition. Iron-overloaded mice were then treated with normal saline (as control), naringin or DFO Morphology changes, and iron deposition in liver tissues were studied using H&E and Perl's staining. The results revealed that naringin is more potent than DFO in removing excessive iron ions deposited in liver tissues, indicating that naringin is a promising natural compound for therapy of iron overload disorders
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Texto completo:
1
Índice:
LILACS
Assunto principal:
Sobrecarga de Ferro
/
Flavanonas
Limite:
Animals
Idioma:
En
Revista:
Braz. J. Pharm. Sci. (Online)
Assunto da revista:
Farmacologia
/
Teraputica
/
Toxicologia
Ano de publicação:
2022
Tipo de documento:
Article