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Características clínicas y epidemiológicas de las neoplasias mieloproliferativas Philadelphia negativas en el sistema público de salud de Chile / Clinical and epidemiological characteristics of the Philadelphia negative myeloproliferative neoplasms in Chile
Valladares, Ximena; Benavente, Rafael; Rojas, Christine; Peña, Camila; Valenzuela, Rodrigo; Monardes, Virginia; López, Hernán; Abarca, Marcelo; León, Pilar; Osorio, Rocío; Pérez, Erika; Soto, Pablo; Rocca, Gabriel La; Cardemil, Daniela; Torres, Vivianne; Intriago, Marvila; Cabrera, María Elena; Undurraga, María Soledad.
Afiliação
  • Valladares, Ximena; Hospital del Salvador. Sección Hematología. Santiago. CL
  • Benavente, Rafael; Hospital del Salvador. Sección Hematología. Santiago. CL
  • Rojas, Christine; Hospital Gustavo Fricke. Sección Hematología. Viña del Mar. CL
  • Peña, Camila; Hospital del Salvador. Sección Hematología. Santiago. CL
  • Valenzuela, Rodrigo; Hospital del Salvador. Laboratorio de Biología Molecular. Santiago. CL
  • Monardes, Virginia; Hospital del Salvador. Laboratorio de Biología Molecular. Santiago. CL
  • López, Hernán; Hospital Barros LucoTrudeau. Sección Hematología. Santiago. CL
  • Abarca, Marcelo; s.af
  • León, Pilar; s.af
  • Osorio, Rocío; s.af
  • Pérez, Erika; s.af
  • Soto, Pablo; s.af
  • Rocca, Gabriel La; s.af
  • Cardemil, Daniela; s.af
  • Torres, Vivianne; s.af
  • Intriago, Marvila; s.af
  • Cabrera, María Elena; s.af
  • Undurraga, María Soledad; s.af
Rev. méd. Chile ; 149(11): 1532-1538, nov. 2021. ilus, graf, tab
Article em Es | LILACS-Express | LILACS | ID: biblio-1389385
Biblioteca responsável: CL1.1
ABSTRACT

BACKGROUND:

Philadelphia-negative myeloproliferative neoplasms (Ph-MPN) are chronic hematological disorders characterized by the overproduction of one or more mature myeloid blood cell lineages. Classical Ph-MPN are polycythemia vera (PV), essential thrombocytopenia (ET) and primary myelofibrosis (PMF).

AIM:

To assess the epidemiological, clinical and diagnostic characteristics of Ph-MPN in Chile. Material and

Methods:

Retrospective review of medical records of all patients referred as MPN from 2012 to 2017. Patients with (9;21) translocation were excluded.

RESULTS:

Data of 462 cases with a median age of 69 years from 10 public hospitals was reviewed. ET was the most frequently Ph-MNP found. The incidence of Ph-MPN was 1.5 x 100.000 cases. The JAK2 V617F mutation study was performed in 96% of patients and only 30% had a bone marrow biopsy. Thrombotic events were observed in 29% of patients. Bleeding events were observed in 7%. Five-year overall survival was 87%.

Conclusions:

ET is the most frequent Ph-MPN. The mean incidence was lower than reported in the literature, in part because of a sub diagnosis.
Palavras-chave

Texto completo: 1 Índice: LILACS País/Região como assunto: America do sul / Chile Idioma: Es Revista: Rev. méd. Chile Assunto da revista: MEDICINA Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Índice: LILACS País/Região como assunto: America do sul / Chile Idioma: Es Revista: Rev. méd. Chile Assunto da revista: MEDICINA Ano de publicação: 2021 Tipo de documento: Article