Formaldehyde analysis of seized cosmetic products by HS-GC-MS of methylal, ethoxymethoxymethane, and ethylal derivatives
Braz. J. Pharm. Sci. (Online)
; 58: e20253, 2022. tab, graf
Article
em En
| LILACS
| ID: biblio-1403711
Biblioteca responsável:
BR40.1
Localização: BR40.1
ABSTRACT
Abstract Formaldehyde is a carcinogenic compound used as preservative in cosmetic products. In this study, a derivatization procedure using MeOH, EtOH and HCl (25251), and incubation at 60ºC for 4 hours was optimized, and the derivatized products - methylal, ethoxymethoxymethane (EMM), and ethylal - were directly analyzed by headspace-gas chromatography-mass spectrometry (HS-GC-MS) to determine formaldehyde concentrations. The validated method provided good linearity of the standard curve, selectivity, recovery (89.6-106.6%), repeatability, and intermediate precision (RSD < 12%), with an LOD of 0.0015% and an LOQ of 0.005% for all derivatized analytes. The validated method showed to be fast, clean, and easy to implement in a laboratory. To the best of our knowledge, this is the first reported HS-GC-MS procedure to determine formaldehyde as methylal, ethylal, and EMM as derivatized compounds. The method was satisfactorily applied for the analysis of nine hair-straightener cream samples seized by the Civil Police of the Federal District, Brazil. Eight samples contained formaldehyde, at levels ranging from 0.33 to 4.02 %, higher than the legal levels, indicating the need to control the levels of this toxic compound in cosmetic products
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Texto completo:
1
Índice:
LILACS
Assunto principal:
Cosméticos
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Formaldeído
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Cromatografia Gasosa-Espectrometria de Massas
Idioma:
En
Revista:
BJPS
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Braz. J. Pharm. Sci. (Impr.)
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Braz. J. Pharm. Sci. (Online)
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Braz. j. pharm. sci. (Online)
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Brazilian Journal of Pharmaceutical Sciences (Impresso)
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Brazilian Journal of Pharmaceutical Sciences (Online)
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Brazilian journal of pharmaceutical sciences (Impresso)
Assunto da revista:
Farmacologia
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Teraputica
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Toxicologia
Ano de publicação:
2022
Tipo de documento:
Article