Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice
J. appl. oral sci
; 30: e20220238, 2022. graf
Article
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LILACS-Express
| LILACS
| ID: biblio-1405378
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Periodontal diseases (PD) are inflammatory conditions that affect the teeth supporting tissues. Increased body fat tissues may contribute to activation of the systemic inflammatory response, leading to comorbidities. Some studies have shown that individuals with obesity present higher incidence of PD than eutrophics. Objective:
To investigate the impact of obesity on periodontal tissues and oral microbiota in mice.Methodology:
Two obesity mice models were performed, one using 12 weeks of the dietary protocol with a high-fat (HF) diet in C57BL/6 mice and the other using leptin receptor-deficient mice (db/db-/-), which became spontaneously obese. After euthanasia, a DNA-DNA hybridization technique was employed to evaluate the microbiota composition and topical application of chlorhexidine (CHX), an antiseptic, was used to investigate the impact of the oral microbiota on the alveolar bone regarding obesity.Results:
Increased adipose tissue may induce alveolar bone loss, neutrophil recruitment, and changes in the oral biofilm, similar to that observed in an experimental model of PD. Topical application of CHX impaired bone changes.Conclusion:
Obesity may induce changes in the oral microbiota and neutrophil recruitment, which are associated with alveolar bone loss.
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Índice:
LILACS
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Revista:
J. appl. oral sci
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
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Project document