Field evaluation of COVID19 antigen tests versus RNA based detection: Potential lower sensitivity compensated by immediate results, technical simplicity, and low cost
J Med Virol.
;
93(4405): 1-17, 2021.
Artigo
em Inglês
| LILACS, CONASS, ColecionaSUS, SES-SP, SESSP-IALPROD, SES-SP
| ID: biblio-1416783
ABSTRACT
One year into the coronavirus disease 2019 (COVID19) pandemic, diagnosticstrategies, although central for contact tracing and other preventive measures, arestill limited. To meet the global demand, lower cost and faster antigen tests forsevere acute respiratory syndrome coronavirus 2 (SARSCoV2) detection are aconvenient alternative to the gold standard reverse transcriptionpolymerase chainreaction (RTPCR) assay. We tested laboratorybased RTPCR RNA detection andtwo rapid antigen detection (RAD) tests, based on the immunochromatography testfor nucleocapsid protein of SARSCoV2 (COVID19 Ag ECO Test, ECO Diagnóstica,and Panbio COVID19 Ag Rapid Test Abbott). Paired collection and testing weredone in a small prospective open study in three clinical services in São Paulo,constituted of mostly symptomatic volunteers at collection (97%, 109/112) for amedian of 4 days (interquartile range 36), ranging from 1 to 30. Among the108 paired RTPCR/RAD tests, results were concordant in 96.4% (101/108). Thetest's performance was comparable, with an overall sensitivity of 87% and aspecificity of 96%. These observations add to other data that suggest that antigentests may provide reasonable sensitivity and specificity and deserve a role toimprove testing strategies, especially in resourcelimited settings.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Reação em Cadeia da Polimerase
/
Busca de Comunicante
/
Coronavirus
/
Pandemias
/
Antígenos
Tipo de estudo:
Estudo diagnóstico
/
Avaliação Econômica em Saúde
Idioma:
Inglês
Revista:
J Med Virol.
Ano de publicação:
2021
Tipo de documento:
Artigo
Instituição/País de afiliação:
Bioprocess and Biotecnology Engeneering,São Paulo State University/BR
/
Infectious Diseases Outpatient Clinic, Santo André Health Secretary/BR
/
Santo André Regional Center, Adolfo Lutz Institute/BR
/
Santo André Regional Center, Adolfo Lutz Institute, Santo André/BR
/
Virology Center, Adolfo Lutz Institute, São Paulo/BR
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