Meta-analysis to Implement Alpha-Synuclein in Extracellular Vesicles as a Potential Biomarker for Parkinson's Disease
Rev. invest. clín
; 75(4): 193-202, Jul.-Aug. 2023. tab, graf
Article
em En
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LILACS-Express
| LILACS
| ID: biblio-1515323
Biblioteca responsável:
MX1.1
ABSTRACT
ABSTRACT Background:
In Parkinson's disease (PD), exosomes carry α-synuclein (α-syn), a fibrillar protein aggregates with potential value as a biomarker.Objective:
Evidence on blood levels of exosomal α-syn in PD patients and controls was reviewed for their consistency.Methods:
Thirty-six studies on exosomal α-syn concentrations in PD were identified in a systematic literature search and meta-analysis.Results:
Both raw and ratio-adjusted blood exosomal α-syn levels were consistently higher in PD patients than in controls. The standardized mean difference (SMD) was 1.54 (0.18-2.90, CI95%, p < 0.01) and 1.53 (0.23-2.83, CI95%, p < 0.01), respectively.Conclusion:
Our results suggest that exosomal α-syn concentrations could be a useful biomarker for PD.
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1
Índice:
LILACS
Tipo de estudo:
Systematic_reviews
Idioma:
En
Revista:
Rev. invest. clín
Assunto da revista:
MEDICINA
Ano de publicação:
2023
Tipo de documento:
Article
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Project document