Use of cerebrospinal fluid CXCL13 concentration for diagnosis and monitoring of neurosyphilis: a three-case report
DST j. bras. doenças sex. transm
;
35jan. 31, 2023. tab
Artigo
em Inglês
| LILACS
| ID: biblio-1523609
ABSTRACT
Introduction:
Previous retrospective studies have demonstrated that the concentration of chemokine ligand CXCL13 in cerebrospinal fluid (CSF-CXCL13) is a promising biomarker in the diagnosis of neurosyphilis and, additionally, in the monitoring of therapeutic efficacy.Objective:
To describe three cases of patients with neurosyphilis (NS) treated at Hospital Universitário Gaffrée e Guinle, in Rio de Janeiro, Brazil, with suspected active syphilis with neurological symptoms. Case report Three patients from Rio de Janeiro, Brazil, were investigated for symptomatic NS. The concentration of CSF-CXCL13 was prospectively performed by enzyme-linked immunosorbent assay (ELISA) in all participants at baseline and in follow-up visits at 3 months after therapy. CSF-CXCL13 concentrations were significantly higher in all three patients with established NS. The CSF-CXCL13 concentrations decreased after 3 months of therapy compared to baseline in all cases reported. The added high concentration of CSF-CXCL13 plus CSF-TPHA reactivity above 140 titer agreed with the diagnosis of NS in 100% of the cases.Conclusion:
In this case series, we present three cases of NS diagnosed using CXCL13 in CSF as a complementary test. These case series suggest that the clinical use of CSF-CXCL13 is useful as a supplementary biomarker for NS and for monitoring the effectiveness of NS therapy, especially in patients with nonreactive CSF-VDRL, excluding other neurologic diseasesAssuntos
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Líquido Cefalorraquidiano
/
Quimiocina CXCL13
/
Neurossífilis
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
DST j. bras. doenças sex. transm
Assunto da revista:
Doenças Sexualmente Transmissíveis
Ano de publicação:
2023
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
EUROIMMUN Brasil/BR
/
Instituto Oswaldo Cruz/BR
/
Universidade do Estado do Rio de Janeiro/BR
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