Efecto del 27- hidroxicolesterol en la acción antiplaquetaria de estradiol en mujeres postmenopáusicas / 27- Hydroxycholesterol reverses estradiol induced inhibition of platelet aggregation in postmenopausal women
Rev. méd. Chile
; 144(11): 1377-1381, nov. 2016. ilus
Article
em Es
| LILACS
| ID: biblio-845458
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
The decline of estrogen levels increases cardiovascular risk in women. Platelets express estrogen receptors and 17β-estradiol- (E2) can produce a protective effect on thrombus formation. The hydroxylation of cholesterol generates several sterols and 27-hydroxycholesterol (27HC) predominates in circulation.Aim:
To evaluate the effect of 27HC as an endogenous antagonist of the anti-aggregating properties of E2 in platelets of postmenopausal women. Material andMethods:
Platelet function of postmenopausal women was evaluated ex-vivo. Platelets pre-incubated with 27HC in the presence or absence of E2, were stimulated with collagen. Aggregation was evaluated using turbidimetry using a Chrono-log aggregometer.Results:
Collagen-stimulated platelet aggregation was significantly inhibited by E2. The inhibitory effect of E2 on collagen-stimulated platelet aggregation was significantly reversed in the presence of 27HC.Conclusions:
The suppressive effect of E2 on platelet aggregation is inhibited by 27HC, which could contribute to increase cardiovascular risk in postmenopausal women.Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Agregação Plaquetária
/
Pós-Menopausa
/
Antagonistas de Estrogênios
/
Estrogênios
/
Hidroxicolesteróis
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2016
Tipo de documento:
Article