Pulmonary oxidative stress in diabetic rats exposed to hyperoxia
Acta cir. bras
; Acta cir. bras;32(7): 503-514, July 2017. tab, graf
Article
em En
| LILACS
| ID: biblio-886213
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Purpose:
To evaluate the pulmonary oxidative stress in diabetic rats exposed to hyperoxia for 90 minutes.Methods:
Forty male Wistar rats were divided into four groups, each one containing 10 animals, according to the oxygen concentration to which they were exposed 21%, 50%, 75% and 100% (hyperoxia). In each group five animals were randomly induced to diabetes by means of at a dose of 55 mg/kg of streptozotocin (STZ).Results:
Seventy two hours after diabetes induction, a significant difference was seen in blood glucose in the experimental groups in comparison with the control. In the experimental groups a significant difference was observed in the concentration of malondialdehyde (MDA) in lung tissue and blood plasma (p<0.05), except the 50% group. In the control group, significant differences in the MDA concentration in plasma and lung tissue were also observed (p<0.05), except the 75% group. The MDA concentration in lung tissue in comparison with the diabetic and non-diabetic groups showed a significant difference in the 21% group; however, no difference was seen in the 75 and 100% groups.Conclusion:
In diabetic animals high oxygen concentrations (75 and 100%) do not appear to exert deleterious effects on lipid peroxidation in lung tissue.Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Estresse Oxidativo
/
Hiperóxia
/
Diabetes Mellitus Experimental
/
Pulmão
Limite:
Animals
Idioma:
En
Revista:
Acta Cir Bras
/
Acta cir. bras
/
Acta cir. bras. (Online)
/
Acta cirúrgica brasileira (Impresso)
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2017
Tipo de documento:
Article