Potential benefit of (-)-epigallocatechin-3-gallate for macrovascular complications in diabetes
Braz. j. med. biol. res
; 50(10): e6511, 2017. tab
Article
em En
| LILACS
| ID: biblio-888942
Biblioteca responsável:
BR1.1
ABSTRACT
Vascular problems are the most common complications in diabetes. Substantial evidence from epidemiological and pathophysiological studies show that hyperglycemia is a major risk factor for macrovascular complications in patients with diabetes. (-)-Epigallocatechin-3-gallate (EGCG), the major catechin derived from green tea, is known to exert a variety of cardiovascular beneficial effects. The protective effects of EGCG in diabetes are also evident. However, whether EGCG is beneficial against macrovascular complications that occur in diabetes remains unknown. Our previous studies demonstrated that treatment of EGCG inhibits high glucose-induced vascular smooth muscle cell proliferation and suppresses high glucose-mediated vascular inflammation in human umbilical vein endothelial cells. Therefore, we hypothesize that EGCG might be an effective potential candidate to reduce the macrovascular complications in diabetes.
Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Catequina
/
Substâncias Protetoras
/
Angiopatias Diabéticas
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2017
Tipo de documento:
Article
/
Project document