Synthesis and anti-myocarditis activity in a multifunctional lanthanide microporous metal-organic framework with 1D helical chain building units
Braz. j. med. biol. res
; 51(3): e7050, 2018. tab, graf
Article
em En
| LILACS
| ID: biblio-889043
Biblioteca responsável:
BR1.1
ABSTRACT
A new microporous lanthanide metal-organic framework, {[Yb(BTB)(H2O) (DEF)2}n (1, DEF=N,N-Diethylformamide), with 1D nano-sized channels has been constructed by bridging helical chain secondary building units with 1,3,5-benzenetrisbenzoic acid (H3BTB) ligand. Structural characterization suggests that this complex crystallizes in the hexagonal space group P6122 and possesses 1D triangular channels with coordinated water molecules pointing to the channel center. In addition, anti-myocarditis properties of compound 1 were evaluated in vivo. The results showed that compound 1 can improve hemodynamic parameters of, and it may be a good therapeutic option for heart failure in the future.
Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Cristalografia por Raios X
/
Elementos da Série dos Lantanídeos
/
Estruturas Metalorgânicas
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Anti-Inflamatórios
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Miocardite
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2018
Tipo de documento:
Article