The clinical efficacy and safety of paclitaxel combined with avastin for NSCLC patients diagnosed with malignant pleural effusion
Rev. Assoc. Med. Bras. (1992, Impr.)
; 64(3): 230-233, Mar. 2018. tab, graf
Article
em En
| LILACS
| ID: biblio-896447
Biblioteca responsável:
BR1.1
ABSTRACT
Summary Objective:
The current study aimed to investigate the clinical efficacy of paclitaxel combined with avastin for non-small cell lung cancer (NSCLC) patients diagnosed with malignant pleural effusion (MPE).Method:
Total of 33 patients diagnosed with NSCLC as well as malignant pleural effusion were included. All of them received paclitaxel (175 mg/m2) and avastin (5 mg/kg). Clinical efficacy was evaluated using the total response rate, overall survival, progression-free survival and changes in MPE volume. Adverse events and rates of toxicities were examined as well.Results:
The total response rate reached 77% while the overall survival and the median progression-free survival were respectively 22.2 months and 8.4 months. Toxicities of grade 3-4 consisted of neutropenia in 57% of patients, anemia in 17% of them, febrile neutropenia in 11%, as well as anorexia in 7%. No treatment-correlated deaths were found.Conclusion:
Paclitaxel combined with avastin decreased MPE volume and increased survival rate of NSCLC patients via inhibiting vascular endothelial growth factor expression.Palavras-chave
Texto completo:
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Índice:
LILACS
Assunto principal:
Protocolos de Quimioterapia Combinada Antineoplásica
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Paclitaxel
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Carcinoma Pulmonar de Células não Pequenas
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Inibidores da Angiogênese
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Bevacizumab
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Neoplasias Pulmonares
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Antineoplásicos Fitogênicos
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
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Aged
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Female
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Humans
/
Male
Idioma:
En
Revista:
Rev. Assoc. Med. Bras. (1992, Impr.)
Assunto da revista:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
MEDICINA
Ano de publicação:
2018
Tipo de documento:
Article