Density of mast cells and intensity of pruritus in psoriasis vulgaris: a cross sectional study
An. bras. dermatol
; 93(3): 368-372, May-June 2018. tab, graf
Article
em En
| LILACS
| ID: biblio-949901
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract BACKGROUND:
Psoriasis is a chronic and prevalent disease, and the associated pruritus is a common, difficult-to-control symptom. The mediators involved in psoriatic pruritus have not been fully established.OBJECTIVE:
To evaluate associations between the number of mast cells in psoriatic lesions and the intensity of pruritus.METHODS:
29 patients with plaque psoriasis were recruited. In all participants, Psoriasis Area and Severity Index and Body Surface Area were assessed. A questionnaire was administered to obtain clinical information and the Dermatology Life Quality Index. Pruritus was assessed using a visual analog scale and skin biopsies were performed for staining with Giemsa and Immunohistochemistry with C-Kit.RESULTS:
Pruritus was observed in 91.3% of our patients. Median VAS was 6 (p25-75 2-8). The immunohistochemical method revealed a mean of 11.32 mast cells/field and Giemsa staining revealed a mean of 6.72 mast cells/field. There was no correlation between the intensity of pruritus and mast cell count, neither in Immunohistochemistry (p = 0.15; rho = -0.27) nor in Giemsa (p = 0.16; rho = -0.27). Pruritus did not impact on the Dermatology Life Quality Index (p = 0.51; rho = -0.13). STUDYLIMITATIONS:
The small sample size may be considered the main limitation of our study.CONCLUSIONS:
Although mast cells are mediators of pruritus in many cutaneous diseases, our findings support that psoriatic pruritus is a complex disorder with multifactorial, complex pathophysiology, involving pruritogenic mediators others than mast cells.Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Prurido
/
Psoríase
/
Pele
/
Mastócitos
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
An. bras. dermatol
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article