Salvianolic acid A alleviates the renal damage in rats with chronic renal failure
Acta cir. bras
; 34(2): e201900204, 2019. tab, graf
Article
em En
| LILACS
| ID: biblio-989051
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Purpose:
To investigate the protective effects of salvianolic acid A (SAA) on renal damage in rats with chronic renal failure (CRF).Methods:
The five-sixth nephrectomy model of CRF was successfully established in group CRF (10 rats) and group CRF+SAA (10 rats). Ten rats were selected as sham-operated group (group S), in which only the capsules of both kidneys were removed. The rats in group CRF+SAA were intragastrically administrated with 10 mg/kg SAA for 8 weeks. The blood urine nitrogen (BUN), urine creatinine (Ucr), creatinine clearance rate (Ccr), and serum uperoxide dismutase (SOD) and malondialdehyde (MDA) were tested. The expressions of transforming growth factor-β1 (TGF-β1), bone morphogenetic protein 7 (BMP-7) and Smad6 protein in renal tissue were determined.Results:
After treatment, compared with group CRF, in group CRF+SAA the BUN, Scr, serum MDA and kidney/body weight ratio were decreased, the Ccr and serum SOD were increased, the TGF-β1 protein expression level in renal tissue was decreased, and the BMP-7 and Smad6 protein levels were increased (all P < 0.05).Conclusion:
SAA can alleviate the renal damage in CRF rats through anti-oxidant stress, down-regulation of TGF-β1 signaling pathway and up-regulation of BMP-7/Smad6 signaling pathway.Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Ácidos Cafeicos
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Proteína Smad6
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Fator de Crescimento Transformador beta1
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Proteína Morfogenética Óssea 7
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Falência Renal Crônica
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Lactatos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2019
Tipo de documento:
Article