Effects of L-carnitine and taurine on associated biochemical changes in alloxan induced diabetic rats
EJB-Egyptian Journal of Biochemistry and Molecular Biology [The]. 2011; 29 (1): 99-113
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| ID: emr-117211
Biblioteca responsável:
EMRO
ABSTRACT
The aim of the present study was to investigate the beneficial effects of L-carnitine and taurine in healthy and alloxan induced diabetes mellitus in rats. Results showed that diabetic rats had significant increase in the levels of plasma glucose, malondialdehyde [MDA], urea, creatinine and the activity of serum asparate aminotransferase and alanine aminotransferase as compared to normal control rats. While, blood glutathione [GSH] content and erythrocyte superoxide dismutase [SOD] activity were significantly lowered. The elevated plasma glucose, MDA, AST, ALT, urea and creatinine levels of diabetic rats were significantly reduced by treatment for 6weeks with L-carnitine and taurine. In addition, normal healthy rats fed on the balanced diet plus L-carnitine and taurine showed significant increase in blood glutathione [GSH] content and erythrocyte superoxide dismutase [SOD] activity as compared with healthy control. It was concluded that dietary administration of L-carnitine and taurine reduces, delays or even prevent oxidative stress in diabetic rats
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Índice:
IMEMR
Assunto principal:
Ratos
/
Superóxido Dismutase
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Taurina
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Carnitina
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Estresse Oxidativo
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Aloxano
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Glutationa
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Testes de Função Renal
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Testes de Função Hepática
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Malondialdeído
Limite:
Animals
Idioma:
En
Revista:
Egypt. J. Biochem. Mol. Biol.
Ano de publicação:
2011