[Comparison of the side effects of blood transfusion between pre-storage filtration and post-storage filtration methods in thalassemia patients]

ABSTRACT

Application of WBC-reduced blood products can decrease side effects related to white blood cells transfer, such as febrile reactions, CMV infection and .. Advances in biotechnology have led to production and development of filters that are capable of reducing WBC; hence, diminishing these side effects. The aim of this study was to determine and compare side effects of blood transfusion between pre-storage filtration and post-storage filtration methods in thalassemia patients. This study was a randomized clinical trial with crossover design and included adult thalassemia patients referring to hospital from 1388 to 1389 and receiving alternately red blood cell concentrates by using pre-storage and post-storage filtration methods. Side effects of blood transfusion including hypotension, fever, hemoglobin drop and blood transfusion rate were recorded and compared between the two methods. Data were introduced in to SPSS software and analyzed by paired t-test, X[2], t-test and P>0.05 was considered significant. Comparison of the incidences of hypotension, FNHTR, allergic reactions and hemoglobin drop between pre-storage and post-storage filtration methods showed no significant differences. A significant difference was observed in the transfusion rates between the two methods which indicated a lower transfusion rate in the pre-storage method [p<0.001]. Pre-storage filtration method is not superior to post-storage filtration method for blood transfusion in thalassemia patients.