Association of the use of bacterial cell wall synthesis Inhibitor drugsin early childhood with the Developmental Defects of Enamel
Pakistan Journal of Medical Sciences. 2014; 30 (2): 393-397
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| ID: emr-138601
Biblioteca responsável:
EMRO
ABSTRACT
Our objective of the study was to determine the association between frequent use of Penicillins and Cephalosporins with developmental defects of enamel in pediatric age group. This is a cross sectional study, conducted at Ziauddin University. A total of 367 children, having the history of either Penicillin or Cephalosporin exposure were included. The parents of children were asked to complete a questionnaire related to disease and drug history. Dental examination was carried out to assess the hypomineralization in tooth enamel based on modified Developmental Defects of Enamel [DDE] index. Out of 367 children, 124 [34%] were males and females were 243[66%]. In the study group 22.6% [n= 83] of children were found to be hypomineralized. The maximum type of teeth defects were diffused opacities that was 12.0% [n=44]. The statistically significant association [p-value < 0.05] was found between frequency of antibiotic use and hypomineralization for most teeth. Children who were exposed to either Penicillins or Cephalosporin in early childhood showed significant [p-value < 0.002] hypomineralized enamel. This study concludes that frequent use of antibiotics such as penicillins and cephalosporins has positive association with enamel hypomineralization in developing tooth structure
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Índice:
IMEMR
Idioma:
En
Revista:
Pak. J. Med. Sci.
Ano de publicação:
2014