Effect of applying lignocaine gel, diclofenac gel or their combination on endotracheal tube on the hemodynamic response and incidence of postoperative complications in patients undergoing CABG surgery
Anaesthesia, Pain and Intensive Care. 2016; 20 (Supp.): 32-36
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| ID: emr-183896
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EMRO
Objectives: Hoarseness of voice, cough and sore throat are well known complications of endotracheal intubation. Many pharmacological strategies are used to reduce the incidence of these complications post surgery. We conducted this study to see the effectiveness of local application of diclofenac sodium gel, lidocaine gel or the effect of these two drugs when applied in combination on tracheal tube during intubation, regarding hemodynamic response and the incidence of postoperative sore throat, hoarseness of voice and cough
Methodology: In this prospective, randomized single blind trial, 150 patients undergoing coronary artery bypass graft [CABG] surgery at Chaudhry Pervaiz Elahi Institute of Cardiology from January 2016 to March 2016, were selected. The patients were divided into three groups; Group X [control Group] in which endotracheal tube [ETT] was lubricated with 2% lignocaine gel. Group D: ETT was lubricated with diclofenac sodium gel [2%]. And Group XD: where a mixture of lignocaine and diclofenac sodium gels was used to lubricate ETT before insertion. Data were analyzed in SPSS V16. One way ANOVA and chi-square test was used for analysis of quantitative and qualitative variables respectively taking p-value < 0.05 to be significant
Results: There was no difference in the age and gender of patients between groups. Post intubation HR increased more in Group D [108.94 +/- 7.40 beats/min.], and least in Group XD 96.62 +/- 3.84 beats/min and 100.72 +/- 6.98 beats/min in group X [p < 0.0001]. HR returned back to baseline value in group X and Group XD within five minutes after intubation but remained higher in diclofenac group [p < 0.0001]. The rise in blood pressure after intubation was highest in Group D [162.46 +/- 5.05 mmHg], then 157.34 +/- 5.43 mmHg in Group X, and least in Group XD [154.12 +/- 6.07 mmHg] [p < 0.0001]. Similarly blood pressure after five minutes of intubation was still high in Group D and was least in Group XD [p < 0.0001]. The time of return of HR and systolic blood pressure to baseline value was 9.00 +/- 1.33 min in Group D, 4.59 +/- 1.03 min in Group X and 3.43 +/- 0.81 min in group XD [p < 0.0001]. Incidence of sore throat, hoarseness of voice and cough was highest in Group X and less in Group D and was least in Group XD [p-values 0.039, 0.025 and 0.002 respectively]
Conclusion: Local application of a combination of lignocaine and diclofenac sodium gels over the endotracheal tube before intubation is associated with better hemodynamic control and significantly lower incidence of postoperative sore throat, hoarseness of voice and cough
Methodology: In this prospective, randomized single blind trial, 150 patients undergoing coronary artery bypass graft [CABG] surgery at Chaudhry Pervaiz Elahi Institute of Cardiology from January 2016 to March 2016, were selected. The patients were divided into three groups; Group X [control Group] in which endotracheal tube [ETT] was lubricated with 2% lignocaine gel. Group D: ETT was lubricated with diclofenac sodium gel [2%]. And Group XD: where a mixture of lignocaine and diclofenac sodium gels was used to lubricate ETT before insertion. Data were analyzed in SPSS V16. One way ANOVA and chi-square test was used for analysis of quantitative and qualitative variables respectively taking p-value < 0.05 to be significant
Results: There was no difference in the age and gender of patients between groups. Post intubation HR increased more in Group D [108.94 +/- 7.40 beats/min.], and least in Group XD 96.62 +/- 3.84 beats/min and 100.72 +/- 6.98 beats/min in group X [p < 0.0001]. HR returned back to baseline value in group X and Group XD within five minutes after intubation but remained higher in diclofenac group [p < 0.0001]. The rise in blood pressure after intubation was highest in Group D [162.46 +/- 5.05 mmHg], then 157.34 +/- 5.43 mmHg in Group X, and least in Group XD [154.12 +/- 6.07 mmHg] [p < 0.0001]. Similarly blood pressure after five minutes of intubation was still high in Group D and was least in Group XD [p < 0.0001]. The time of return of HR and systolic blood pressure to baseline value was 9.00 +/- 1.33 min in Group D, 4.59 +/- 1.03 min in Group X and 3.43 +/- 0.81 min in group XD [p < 0.0001]. Incidence of sore throat, hoarseness of voice and cough was highest in Group X and less in Group D and was least in Group XD [p-values 0.039, 0.025 and 0.002 respectively]
Conclusion: Local application of a combination of lignocaine and diclofenac sodium gels over the endotracheal tube before intubation is associated with better hemodynamic control and significantly lower incidence of postoperative sore throat, hoarseness of voice and cough
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Índice:
IMEMR
Tipo de estudo:
Clinical_trials
/
Incidence_studies
/
Qualitative_research
Idioma:
En
Revista:
Anaesth. Pain Intensive Care
Ano de publicação:
2016