[Effects of losartan on spatial memory deficits induced by global ischemia / reperfusion in male wistar rats]

ABSTRACT

Background: Stroke is the most important reason of cerebral ischemia and following reperfusion lead to programmed cell death. Harm to hippocampus causes major disruption in the performance of active memory tests. So in this study, we investigated the effect of losartan [angiotensin antagonists II] on spatial memory deficits and neuronal damage caused by ischemia /reperfusion in rats