Development of stable theophylline suppositories

Nine theophylline and seven aminophylline suppository formulations were prepared. The base used were polyethylene glycol blend, Suppocire A, NA10 and AP, Witepsol H15 and Estaram H15. The fatty bases were used either alone or in combination with each other. In some theophylline formulations, 1% docusate sodium, as a release enhancer, was incorporated. The effect of some additives on the stability of aminophylline suppositories was investigated. All formulations were tested for their drug release and melting points over a period of one year. The results revealed that formulations prepared with aminophylline in PEG, theophylline in PEG or Suppocire AP possess the best stability and fastest drug release. Besides, these formulations were recommended for the development of theophylline suppositories