Effect of long-term administration of onion extract on some serum biochemical constituents in rats

ABSTRACT

Experiments were performed to show the effect of long-term administration of fresh and boiled onion extract in dose of 4 ml/day, for one and two months, on some serum constituents. These constituents were insulin, glucose, total lipids, total cholesterol and some enzyme activities. Results indicated that insulin concentration was significantly [P <0.01] increased in rats given fresh onion extract for one and two months and boiled for two months only. Glucose level was significantly [P <0.05] decreased after the 1st month and highly decreased [P <0.01] after the 2nd month in rats administrated both onion extract. AS-T activity was significantly [P <0.01] increased in serum of rats intubated fresh and boiled onion extract whereas, the AL-T activity was significantly [P <0.01] reduced in rats given boiled onion extract. The lactic dehydrogenase activity showed nonsignificant changes during all the experiment. Both onion extract [fresh and boiled] caused significant [P <0.05] decrement in the total lipids and cholesterol values after the first month and highly decreased [P <0.01] after the second month