prostaglandin synthesis inhibitor: Indomethacin and imipramine in the treatment of primary nocturnal enuresis

ABSTRACT

In this study, we tried to determine efficacy of indomethacin, a prostaglandin synthesis inhibitor with a tricyclic antidepressant imipramine together in the treatment of primary nocturnal enuresis. This study included 78 patients with primary nocturnal enuresis [PNE] living in the same environmental and social condition. Imipramine [50 mg per night] and indomethacin [25 mg per night] was administered during 8 weeks. At the end of this time, medical therapy was gradually finished and dryness was followed-up. We conclude that indomethacin is a good alternative agent for nocturnal enuresis particularly as a supplementary treatment combined with imipramine, with 78.6% complete response and 74.7% dryness rate