Efect of ranitidine and tiotidine on spermatogenesis in ablino rats

ABSTRACT

Effect of ranitidine and tiotidine on spermatogenesis in albino rats was determined under local management and climatic conditions. These H2 blocking drugs were administrated to the albino rats in dose of 2.14 and 1.42 mg/kg body weight, twice daily for a period of five weeks. The results revealed that ranitidine caused a significant decrease [P< 0.05] in the number of spermatocytes while tiotidine had no effect on the germ cells in the seminiferous tubules. It is, therefore, likely that ranitidine and tiotidine have antispermatogenic activity